Tuesday night Chael Sonnen came to the defense of under-fire Heavyweight Alistair Overeem, who awaits the decision of the NSAC concerning his license to fight at UFC 146. Blaming the media, Sonnen essentially considered Overeem's issue to be an overblown phenomenon created by MMA media. Familiar with the issue of elevated T:E levels, Sonnen had the following to say on Fuel TV's “UFC Tonight”:
"Congratulations to MMA media, right when I think your incompetence can't get to any higher level, the Alistair Overeem story comes out. You kids on the interweb, running your little 'dot com's' from the couch in your mother's basement, you beneficiaries of Mark Cuban's tax write-off, you've gone and screwed up the Alistair Overeem case, beyond belief. Is it repairable? I doubt it."
Sonnen's anger at the subject seems to stem from the exact definition of the failed test in question, something that Overeem's manager addressed earlier this week. No official announcement has been made, but it seems that if Overeem did not test positive for elevated testosterone or any other banned substance, the defense of TRT will come to the forefront.
"Hey. If I'm a member of the media and someone tells me that Alistair Overeem failed a drug test, the very first thing I'm going to say is: ‘Really? What substance did he test positive for?' Now, you see, those basic questions are where the wheels begin to fall off the bus to this entire story. Alistair Overeem did not test positive for anything. End of story. So why is his name getting drug through the mud? Why are they saying, 'Well, he's got an elevated T-to-E ratio. Ok, fair enough. Let's say his T-to-E ratio is outside the norm. That's not illegal. That's outside the norm. That's a red flag. That is a red flag, and Alistair will owe an explanation. If it's not against the rules, why are we having this conversation? MMA Media: Ya failed!”
It appears that many fine lines are being walked regarding what is illegal and frowned upon, with Sonnen coming to the side of Overeem. Perhaps this is due to his own dealings with TRT after he was found to have 16.9:1 T:E levels after his hard-fought loss against Anderson Silva in 2010. It is true that no specific substances have been found in Overeem's test as of yet, just the red flags that Sonnen mentioned. Again, the debate over TRT rages on. Did Alistair Overeem do wrong here, or is he playing just inside the rules?
Comments
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Unfortunately, I see this being one of the arguments that Reem will make as well... He will come to the hearing drug free, take another drug test, and likely be at normal levels. I'm pretty sure this is also why Dana White hasn't made a replacement, he feels that this fight will still take place as well.
Odd to hear these declarations from Chael, because he was one of the first people who attacked the Reem through Twitter. I'm sure anyone can find and read the tweet on the Net. Yet another blatant self-contraction from the great Chael...
This could have been fixed using a certain kind of test (sorry can't remember name) that can tell if there is any synthetic or not self-produced testosterone in the body.
If they had given him that test STRAIGHT after the first results came back high then we wouldn't need to be discussing this, he would be either innocent or guilty.
Here you go.... http://www.bloodyelbow.com/2012/4/7/2932752/ufc-tweet-of-the-day-chael-sonnen-alistair-overeem-drug-test-mma-news I dont even listen to Chael anymore.
like i told yall before sonnen was 16.9:1 which is 17 times the norm and 4 times the limit far as overeem i just think they got a loophole kinda what diaz is trying to do
This sounds like semantics but Sonnen was not 17 times the norm. There is no "norm" for T:E ratio. The 1:1 ratio and 4:1 ratio we hear about is a standard set by the athletic commissions. It is not used in medicine to determine if someone is normal or abnormal.
When you say it is 17 times normal it sound like it is 18,360 (Normal is 260-1080 in American units and 8-36 in SI units). I've tried to find Sonnen's actual blood level of Testosterone (not the T:E ratio) but have not been able to. Remember that Tour de France winner Floyd Landis had a high T:E ratio and a normal Testosterone (steroid) Level.
Does anyone have a reference to Sonnen's or Overeem's actual testosterone level? That would be interesting.
High T to E ratio is ALMOST always due to steriod use having an effect on their body's natural level of T to E. Doesnt mean theyre currently on something, but usually just coming off.
That's what I was actually trying to get out of you the other day. I'm not sure there is any information out there on either as they would have to come from blood testing correct?
ive never seen any blood test results out of a fighter, but they CAN tell a lotmore of the story. The problem is fighters that KNOW what theyre taking usually know how long it stays in their system, allowing them to go without getting caught until they screw up. Many different steroids have different detection times...most pro athletes know this and have for decades. Its been going on in the nfl and mlb forever. My rule of thumb...when you have athletes bigger than "natural bodybuilders", most of them which are on PEDs themselves...when its a bodybuilders only job to get as big as possible...theres a GREAT chance theyre juicing....reem, broc, duffee, alves, votor back in his early days. Truth is, a very high percentage of mma fighters juice...trt or not...its cheating...
if Overeem didn't test positive for any banned substance. You either accept that he didn't do anything wrong or you say that the testing is not up to the task.
This is ignorance. I'm assuming you dont know much about the topic yourself. My best advice in this case is to not just follow what everyone says and actually do research into the topic. This is an epidemic in MMA and will eventually need to be fixed.
I know nothing about trt, so I have no 2 cents to put in here. But I wonder if JDS will want to defend his belt against a possible cheater ; regardless of what the commission's findings are.
What Sonnen should have said is that Overeem didn't test positive for any banned substance YET. Lets see what the follow up tests find. Nobody tests positive for a banned substance in the first test because they are not testing for banned substance in the "A" cup. That test only comes later IF the T:E ratio is out of whack.
My guess is that if sample A has a high T:E he has two choices: Do the B sample for actual type of T OR walk away from fighting in their jurisdiction (and perhaps your career in North America).
He supposedly has a valid reason for the high ratio. If he provides proof of TRT or something else that can explain it, he'll be fine. He, his management, and the UFC feel very confident he'll be fighting come May 26th.
I can't always say this haha, but I agree w Chael 100%...and this is how I have felt since this BS started. Some worthless f*cks just can't wait to attack and lable ppl, its a f*cking witchunt.
Rampage told everyone all about his TRT and that his UFC doc recommended it, which as far as know was never disputed (we don't know if thats what Reem's issue is about), but if understand correctly TRT requires some dialing in to get levels right. As long as Reem's levels are legal come fight time then WTF?? Who cares? If this is such an issue then they just need to ban TRT outright.
Lol. They simply need to be consistent and have clear rules and regulations either way. But at this point, going by the book, nobody can call Reem a cheat. He hasn't tested positive for a banned substance and he has not violated any rule.
the problem with that....as far as athletes go...theyre not testosterone deficient. In the cases in which they are, it's ALMOST ALWAYS because they abused/abuse steroids year round.
Do u know what type of ppl are testosterone deficient? Better idea...name someone in MMA that has a "right" reason to use steroids...plz.
I agree with mike mercado on this one. First of all, how does Kenny know he can get 10 more fights out of his career if he took T?? He's guessing or making it up. Secondly, Kenny said he was retiring due to a bad back. TRT will do nothing for that. This is the kind of inflammitory "News Reporting" Sonnen is complaining about. "Newscasters" that make up parts of the news.
What are masking agents? Masking agents are drugs or compounds that are taken with the express purpose of hiding or "masking" the presence of specific illegal drugs that are screened for athletic drug testing (4). Masking agents have the potential to impair or conceal the banned substance in the urine (4). The most common masking agents include diuretics, epitestosterone, probenecid and plasma volume expanders (4, 8). Each of these categories is addressed.
How do masking agents it work? Diuretics: Diuretics have been placed on the prohibited list for some time because of two reasons: 1) they facilitate weight loss via their ability to enhance rapid water loss via urine excretion and 2) they have the potential to rapidly dilute the urine by increasing renal flow. When utilized as a "masking" agent diuretics dilute the urine, which results in lower levels of the banned substance being excreted from the body. This can therefore make it more difficult for the laboratories conducting doping controls to detect (8).
Epitestosterone: When athletes take exogenous testosterone two basic methods can be employed to "mask" the use of these compounds: 1) Utilize transdermal delivery mechanisms or 2) use epitestosterone in conjunction with testosterone use.
One mechanism for "masking" testosterone use is to use transdermal preparations which have the potential to raise circulating testosterone and are only detectable by doping controls via blood profiles in the period of 4-8 hours after administration (2). If the athlete were to utilize transdermal solutions in a systematic method they may be able to administer a low dosage of testosterone that would be below the testing standards.
Probenecid: Probenecid has been shown to reduce the excretion of anabolic steroids into the urine (3), thus potentially reducing the level of androgens below the levels established. In animal studies it has been reported that the co-administration of probenecid and the anabolic steroid stanozolol results in an increased disappearance of the anabolic steroid from the plasma. Additionally, the co-administration of these drugs results in a decrease in the total amount of stanozolol excreted into the urine (7).
Alpha-Reductase Inhibitors: Alpha-reductase inhibitors are generally used for the treatment of prostate hypertrophy and androgenic alopecia (1). It appears that alph-reductase inhibitors have the potential to significantly impact steroid profiles which are used in drug testing. Specifically, they appear to complicate or even prevent the detection of some prohibited substances.
Plasma Volume Expanders: Plasma volume expanders (i.e. albumin, dextran or hydroxyethyl startch) can be used by athletes for several reasons: 1) to prevent dehydration (6) or 2) in order to mask recombinant erythropoietin use (5). When plasma volume expanders are taken with recombinant erythropoietin they can elevate the blood volume while maintaining a blood profile level that is within the legal range (6).
How are masking agents commonly used? Diuretics: The dosage of diuretic administered varies depending upon the actual drug that is administered. When looking at the diuretic furmosimide the clinical dosage for adults is to give 20-80 mg as a single dosage. However, if needed the same dosage can be give 6-8 hours later. With this dosage scheme a very rapid secretion of urine occurs (1).
Epitestosterone: No pharmaceutical dosages for epitestosterone are available because epitestosterone is only available as a chemical (2).
Alpha-Reductase Inhibitors: The recommended medical dosage for the common alpha-reductase inhibitor, Dutasteride is 0.5 mg taken once daily. However, studies have shown that between 5-40 mg of Dutasteride can be taken per day with minimal adverse side effects. The recommended clinical dosage of Finasteride, another common alpha-reductase inhibitor, is 1 mg per day. Dosages of 80-400 mg per day have been shown to produce minimal adverse reactions (1).
Plasma Expanders: Generally plasma expanders such as albumin are administered with other compounds such as blood, plasma, or saline. Generally, the total dose and rate of infusion relies on the individual's condition and response to treatment. When plasma expanders are administered to adults for medical reasons the general amount used is between 250-500 ml, but dosages should be individualized (1).
What are the potential side effects of masking agents? Diuretics: The utilization of diuretics may result in the occurrence of heart arrhythmias, dehydration, muscle cramping, blood volume depletion, significant drops in blood pressure and severe electrolyte imbalances. These arrhythmias can occur as a result of a deficiency of potassium in the blood and dehydration (4).
Probenecid: Probenecid use generally results in very few minor side effects. These side effects can include the formation of kidney stones, acute gouty arthritis, hair loss, skin rash, headache, nausea, sore gums, fever and in very rare cases severe anemias (1).
Alpha-Reductase Inhibitors: The most significant side effects associated with the use of some of these masking agents are associated with reproductive dysfunction (1). Reproductive side effects include a decreased libido, increased occurrence of erectile dysfunction, and an increase occurrence in ejaculation disorders (1).
Plasma Expanders: The use of plasma expanders such as albumin can very rarely result in adverse effects. These effects are usually marked by nausea, fever, chills or hives.
.........
Hopefully this sheds light...pro athletes already use many of these masking agents...
ARI's block the 5 alpha reductase enzyme that converts testosterone to dihydrotestosterone (DHT) and will leave more testosterone as testosterone. You would be foolish to use this to mask since it will prevent the prostate enlargement caused by high DHT levels but make your T levels marginally higher. A waste of your money.
Diuretics will help by diluting urine but detailed testing of the blood will be unaffected. A waste of your money. Great for cutting weight though.
Albumin reversibly binds T but this would be caught with a Bio_available T level since Bio-T measures the T bound to albumin and the free T. A waste of money.
Taking EpiTestosterone will help you avoid getting caught in cup A by bringing the T: EpiT ratio down but once you have been caught in cup A you are already past that step. A waste of money.
Probenacid is also used to decreased the amount of T in the urine. Good for cup A but useless once you're caught. Blood will catch you now! A waste of money.
This is why Dr. Google isn't reliable. It doesn't think. If NSAC tests Overeem's blood I can't think of any way out of that. If sufficient times goes by his levels will drop but T is stored up in body fat and levels drop somewhat slower than, say alcohol. I would think / hope that NSAC would be clever enough to ask him for a blood sample right away OR not license him.
The thing was Bruce, he actually wasn't licensed in the first place, so he had no reason to provide (for example) documentation about TRT which would explain the high ratio. Now I beleive he still has some time to get the appropriate documentation to the NSAC. Remember he was given a conditional license to fight Brock Lesnar in December.
Taking EpiTestosterone will help you avoid getting caught in cup A by bringing the T: EpiT ratio down but once you have been caught in cup A you are already past that step. A waste of money.
^this right here will allow you to pass test A....therefore no test B to follow.
Probenacid is also used to decreased the amount of T in the urine. Good for cup A but useless once you're caught. Blood will catch you now! A waste of money.
^ also another way to avoid cup B.
Just because you pass a test like urine, doesnt mean u didnt cheat...
Look at your original post. You were talking about Reem's levels getting back down. He's already done sample A. Mike, you're having trouble following your own argument, go get another caffeinated beverage!
I may have strayed away sligtly for cup A, but for T levels...just being off the roids with time, can actually.have him well under a "normal" range for he'll be shut down completely after using artificial testosterone. He would just use a pct(post cycle therapy) approach such as nolva to get his natural test jump started. The reason he probably wouldnt be "under" is because he can inject himself with the maximum legal amout of T in his body. Since he' OBVIOUSLY used roids in the past and will need TRT now due to his abuse, it'll be easy to get a prescription.
At the end of the day, TRT shouldnt be legal. Period. It leaves so much room for abuse and cheating.
would u like instructions on how to get a legit dr to give you a.legit prescription for TRT too? Hahaha ...i fukin hate cheaters...and a hard newsflash for many...they dont even have to look like todd duffee to be on roids...sad but true.
Masking agent simply means it hides the drug, it doesn't physically bring it back to normal. Thats why blood testing is being done now from what I understand.
LOL @ A MOUTHY DEGENERATE CHEATER CALLING ANYONE INCOMPETENT. SONNED YOU CHEATED YOU DID STEROIDS YOU DONT BELONG COMMENTING ON ANYTHING YOU ****ING RETARD.
Tuesday night Chael Sonnen came to the defense of under-fire Heavyweight Alistair Overeem, who awaits the decision of the NSAC concerning his license to fight at UFC 146. Blaming the media, Sonnen essentially considered Overeem's issue to be an overblown phenomenon created by MMA media. Familiar with the issue of elevated T:E levels, Sonnen had the following to say on Fuel TV's “UFC Tonight”:
Comments
Unfortunately, I see this being one of the arguments that Reem will make as well... He will come to the hearing drug free, take another drug test, and likely be at normal levels. I'm pretty sure this is also why Dana White hasn't made a replacement, he feels that this fight will still take place as well.
@Ajichiba, this joke has already been done, ya failed !! ;)
Chael might want to back off the internet and media. HIS BOSS went off and got the whole thing labeled as legit.
Odd to hear these declarations from Chael, because he was one of the first people who attacked the Reem through Twitter. I'm sure anyone can find and read the tweet on the Net. Yet another blatant self-contraction from the great Chael...
This could have been fixed using a certain kind of test (sorry can't remember name) that can tell if there is any synthetic or not self-produced testosterone in the body.
If they had given him that test STRAIGHT after the first results came back high then we wouldn't need to be discussing this, he would be either innocent or guilty.
Here you go.... http://www.bloodyelbow.com/2012/4/7/2932752/ufc-tweet-of-the-day-chael-sonnen-alistair-overeem-drug-test-mma-news I dont even listen to Chael anymore.
like i told yall before sonnen was 16.9:1 which is 17 times the norm and 4 times the limit far as overeem i just think they got a loophole kinda what diaz is trying to do
This sounds like semantics but Sonnen was not 17 times the norm. There is no "norm" for T:E ratio. The 1:1 ratio and 4:1 ratio we hear about is a standard set by the athletic commissions. It is not used in medicine to determine if someone is normal or abnormal.
When you say it is 17 times normal it sound like it is 18,360 (Normal is 260-1080 in American units and 8-36 in SI units). I've tried to find Sonnen's actual blood level of Testosterone (not the T:E ratio) but have not been able to. Remember that Tour de France winner Floyd Landis had a high T:E ratio and a normal Testosterone (steroid) Level.
Does anyone have a reference to Sonnen's or Overeem's actual testosterone level? That would be interesting.
High T to E ratio is ALMOST always due to steriod use having an effect on their body's natural level of T to E. Doesnt mean theyre currently on something, but usually just coming off.
That's what I was actually trying to get out of you the other day. I'm not sure there is any information out there on either as they would have to come from blood testing correct?
ive never seen any blood test results out of a fighter, but they CAN tell a lotmore of the story. The problem is fighters that KNOW what theyre taking usually know how long it stays in their system, allowing them to go without getting caught until they screw up. Many different steroids have different detection times...most pro athletes know this and have for decades. Its been going on in the nfl and mlb forever. My rule of thumb...when you have athletes bigger than "natural bodybuilders", most of them which are on PEDs themselves...when its a bodybuilders only job to get as big as possible...theres a GREAT chance theyre juicing....reem, broc, duffee, alves, votor back in his early days. Truth is, a very high percentage of mma fighters juice...trt or not...its cheating...
Ya, the random test was just urine, need blood for actual testosterone levels.
if Overeem didn't test positive for any banned substance. You either accept that he didn't do anything wrong or you say that the testing is not up to the task.
This is ignorance. I'm assuming you dont know much about the topic yourself. My best advice in this case is to not just follow what everyone says and actually do research into the topic. This is an epidemic in MMA and will eventually need to be fixed.
I know nothing about trt, so I have no 2 cents to put in here. But I wonder if JDS will want to defend his belt against a possible cheater ; regardless of what the commission's findings are.
What Sonnen should have said is that Overeem didn't test positive for any banned substance YET. Lets see what the follow up tests find. Nobody tests positive for a banned substance in the first test because they are not testing for banned substance in the "A" cup. That test only comes later IF the T:E ratio is out of whack.
I don't think Overeem asked that the B sample be tested though. Did Nevada just test it on its own?
Hes saying if you fail cup A then you have to do cup B
My guess is that if sample A has a high T:E he has two choices: Do the B sample for actual type of T OR walk away from fighting in their jurisdiction (and perhaps your career in North America).
He supposedly has a valid reason for the high ratio. If he provides proof of TRT or something else that can explain it, he'll be fine. He, his management, and the UFC feel very confident he'll be fighting come May 26th.
He may have a point but this is the last guy Reem needs defending him. It's like OJ coming to the defense of Zimmerman.
Is this mean they are using the same product :)
And befor you weak me dear lowkick reader, i must tell IMO Reem deserve this title fight no mather what...
Now go on and weak me...
Not to sound like a prick or anything, but why do some of us lowkick users worry so much about getting a few weaks next to our comments?
How cool of you, Chael, to be one of the first fighters to speak out in favor of Overeem's positive test, ironic anyone?
Neh, just a guy who also had an astronomical T/E ratio. He's trying to be out in front because he thinks Overeem will still get to fight.
I think if he does it will be a real detriment to the sport though.
I can't always say this haha, but I agree w Chael 100%...and this is how I have felt since this BS started. Some worthless f*cks just can't wait to attack and lable ppl, its a f*cking witchunt.
Rampage told everyone all about his TRT and that his UFC doc recommended it, which as far as know was never disputed (we don't know if thats what Reem's issue is about), but if understand correctly TRT requires some dialing in to get levels right. As long as Reem's levels are legal come fight time then WTF?? Who cares? If this is such an issue then they just need to ban TRT outright.
You're kidding...right?
No, Mike
"If this is such an issue then they just need to ban TRT outright. "
This.
Yes!
I Agree they need to educate everyone more about TRT.
Educate them how its pure cheating.
I'm not saying its right in every case? To show why people use and need it. So you should find out what i mean by it first.
Lol. They simply need to be consistent and have clear rules and regulations either way. But at this point, going by the book, nobody can call Reem a cheat. He hasn't tested positive for a banned substance and he has not violated any rule.
the problem with that....as far as athletes go...theyre not testosterone deficient. In the cases in which they are, it's ALMOST ALWAYS because they abused/abuse steroids year round.
Do u know what type of ppl are testosterone deficient? Better idea...name someone in MMA that has a "right" reason to use steroids...plz.
Are you a doctor, Mike?
What? Like the dr that was/is being prosecuted for giving pro athletes inclusing shane carwin HGH and shit? Ilegally?
No, Mike
Find out what he means, Mike!
Birds of a feather..
Maybe a hair thats course that came from a horse?
....go chatter and cheap
,,,flock together.
If this fight happens it will be a great day for those who say MMA is not a sport!
If this shit (fight) happens...ill buy the next mayweather fight and.actually cheer for him....
Kind of surprised how many people rather bypass testing for their Reem love.
I have to agree with Kenny Florian on this one.
The Reem cheated. What he was doing enabled him to train harder and recover quicker. Same as Chael (although it didn't help him).
Kenny even said in an interview he could probably squeeze another 10 fights out his career if he started ARTIFICIALLY replacing tesosterone.
Chael needs to get a grip and stop trying to be controversial at every opportunity. Chin up Chael!
he's just trying to be relevant and get exposure. Any publicity is good publicity...his purse will just get bigger.
I agree with mike mercado on this one. First of all, how does Kenny know he can get 10 more fights out of his career if he took T?? He's guessing or making it up. Secondly, Kenny said he was retiring due to a bad back. TRT will do nothing for that. This is the kind of inflammitory "News Reporting" Sonnen is complaining about. "Newscasters" that make up parts of the news.
I think his ratios are way off because of his Roid use forever.
Yes, but his levels will be normal soon. There are different things out there to bring you body's natural chemistry back in line.
Like what?
Maybe a time machine that will take him all the way back to LHW 8))
What are masking agents? Masking agents are drugs or compounds that are taken with the express purpose of hiding or "masking" the presence of specific illegal drugs that are screened for athletic drug testing (4). Masking agents have the potential to impair or conceal the banned substance in the urine (4). The most common masking agents include diuretics, epitestosterone, probenecid and plasma volume expanders (4, 8). Each of these categories is addressed.
How do masking agents it work? Diuretics: Diuretics have been placed on the prohibited list for some time because of two reasons: 1) they facilitate weight loss via their ability to enhance rapid water loss via urine excretion and 2) they have the potential to rapidly dilute the urine by increasing renal flow. When utilized as a "masking" agent diuretics dilute the urine, which results in lower levels of the banned substance being excreted from the body. This can therefore make it more difficult for the laboratories conducting doping controls to detect (8).
Epitestosterone: When athletes take exogenous testosterone two basic methods can be employed to "mask" the use of these compounds: 1) Utilize transdermal delivery mechanisms or 2) use epitestosterone in conjunction with testosterone use.
One mechanism for "masking" testosterone use is to use transdermal preparations which have the potential to raise circulating testosterone and are only detectable by doping controls via blood profiles in the period of 4-8 hours after administration (2). If the athlete were to utilize transdermal solutions in a systematic method they may be able to administer a low dosage of testosterone that would be below the testing standards.
Probenecid: Probenecid has been shown to reduce the excretion of anabolic steroids into the urine (3), thus potentially reducing the level of androgens below the levels established. In animal studies it has been reported that the co-administration of probenecid and the anabolic steroid stanozolol results in an increased disappearance of the anabolic steroid from the plasma. Additionally, the co-administration of these drugs results in a decrease in the total amount of stanozolol excreted into the urine (7).
Alpha-Reductase Inhibitors: Alpha-reductase inhibitors are generally used for the treatment of prostate hypertrophy and androgenic alopecia (1). It appears that alph-reductase inhibitors have the potential to significantly impact steroid profiles which are used in drug testing. Specifically, they appear to complicate or even prevent the detection of some prohibited substances.
Plasma Volume Expanders: Plasma volume expanders (i.e. albumin, dextran or hydroxyethyl startch) can be used by athletes for several reasons: 1) to prevent dehydration (6) or 2) in order to mask recombinant erythropoietin use (5). When plasma volume expanders are taken with recombinant erythropoietin they can elevate the blood volume while maintaining a blood profile level that is within the legal range (6).
How are masking agents commonly used? Diuretics: The dosage of diuretic administered varies depending upon the actual drug that is administered. When looking at the diuretic furmosimide the clinical dosage for adults is to give 20-80 mg as a single dosage. However, if needed the same dosage can be give 6-8 hours later. With this dosage scheme a very rapid secretion of urine occurs (1).
Epitestosterone: No pharmaceutical dosages for epitestosterone are available because epitestosterone is only available as a chemical (2).
Alpha-Reductase Inhibitors: The recommended medical dosage for the common alpha-reductase inhibitor, Dutasteride is 0.5 mg taken once daily. However, studies have shown that between 5-40 mg of Dutasteride can be taken per day with minimal adverse side effects. The recommended clinical dosage of Finasteride, another common alpha-reductase inhibitor, is 1 mg per day. Dosages of 80-400 mg per day have been shown to produce minimal adverse reactions (1).
Plasma Expanders: Generally plasma expanders such as albumin are administered with other compounds such as blood, plasma, or saline. Generally, the total dose and rate of infusion relies on the individual's condition and response to treatment. When plasma expanders are administered to adults for medical reasons the general amount used is between 250-500 ml, but dosages should be individualized (1).
What are the potential side effects of masking agents? Diuretics: The utilization of diuretics may result in the occurrence of heart arrhythmias, dehydration, muscle cramping, blood volume depletion, significant drops in blood pressure and severe electrolyte imbalances. These arrhythmias can occur as a result of a deficiency of potassium in the blood and dehydration (4).
Probenecid: Probenecid use generally results in very few minor side effects. These side effects can include the formation of kidney stones, acute gouty arthritis, hair loss, skin rash, headache, nausea, sore gums, fever and in very rare cases severe anemias (1).
Alpha-Reductase Inhibitors: The most significant side effects associated with the use of some of these masking agents are associated with reproductive dysfunction (1). Reproductive side effects include a decreased libido, increased occurrence of erectile dysfunction, and an increase occurrence in ejaculation disorders (1).
Plasma Expanders: The use of plasma expanders such as albumin can very rarely result in adverse effects. These effects are usually marked by nausea, fever, chills or hives.
.........
Hopefully this sheds light...pro athletes already use many of these masking agents...
Nice copy paste ( * ) ( * )
Sweet tits
Holy Mackeral you're chatty today.
ARI's block the 5 alpha reductase enzyme that converts testosterone to dihydrotestosterone (DHT) and will leave more testosterone as testosterone. You would be foolish to use this to mask since it will prevent the prostate enlargement caused by high DHT levels but make your T levels marginally higher. A waste of your money.
Diuretics will help by diluting urine but detailed testing of the blood will be unaffected. A waste of your money. Great for cutting weight though.
Albumin reversibly binds T but this would be caught with a Bio_available T level since Bio-T measures the T bound to albumin and the free T. A waste of money.
Taking EpiTestosterone will help you avoid getting caught in cup A by bringing the T: EpiT ratio down but once you have been caught in cup A you are already past that step. A waste of money.
Probenacid is also used to decreased the amount of T in the urine. Good for cup A but useless once you're caught. Blood will catch you now! A waste of money.
This is why Dr. Google isn't reliable. It doesn't think. If NSAC tests Overeem's blood I can't think of any way out of that. If sufficient times goes by his levels will drop but T is stored up in body fat and levels drop somewhat slower than, say alcohol. I would think / hope that NSAC would be clever enough to ask him for a blood sample right away OR not license him.
no copy paste = Dr. BruceLee
The thing was Bruce, he actually wasn't licensed in the first place, so he had no reason to provide (for example) documentation about TRT which would explain the high ratio. Now I beleive he still has some time to get the appropriate documentation to the NSAC. Remember he was given a conditional license to fight Brock Lesnar in December.
Taking EpiTestosterone will help you avoid getting caught in cup A by bringing the T: EpiT ratio down but once you have been caught in cup A you are already past that step. A waste of money.
^this right here will allow you to pass test A....therefore no test B to follow.
Probenacid is also used to decreased the amount of T in the urine. Good for cup A but useless once you're caught. Blood will catch you now! A waste of money.
^ also another way to avoid cup B.
Just because you pass a test like urine, doesnt mean u didnt cheat...
Ditto
Look at your original post. You were talking about Reem's levels getting back down. He's already done sample A. Mike, you're having trouble following your own argument, go get another caffeinated beverage!
I may have strayed away sligtly for cup A, but for T levels...just being off the roids with time, can actually.have him well under a "normal" range for he'll be shut down completely after using artificial testosterone. He would just use a pct(post cycle therapy) approach such as nolva to get his natural test jump started. The reason he probably wouldnt be "under" is because he can inject himself with the maximum legal amout of T in his body. Since he' OBVIOUSLY used roids in the past and will need TRT now due to his abuse, it'll be easy to get a prescription.
At the end of the day, TRT shouldnt be legal. Period. It leaves so much room for abuse and cheating.
*slightly...
The TRT claim seems like his likely defense, eh?
Ya, dont see what else it could be.
would u like instructions on how to get a legit dr to give you a.legit prescription for TRT too? Hahaha ...i fukin hate cheaters...and a hard newsflash for many...they dont even have to look like todd duffee to be on roids...sad but true.
Masking agent simply means it hides the drug, it doesn't physically bring it back to normal. Thats why blood testing is being done now from what I understand.
To my knowledge blood test arent usually done, but they probably will be in reems case.
1 other thing ppl use, is simply time...eventually levels start balancing out, and pct'ing after a cycle can also help kick start the process.
LOL @ A MOUTHY DEGENERATE CHEATER CALLING ANYONE INCOMPETENT. SONNED YOU CHEATED YOU DID STEROIDS YOU DONT BELONG COMMENTING ON ANYTHING YOU ****ING RETARD.
14:1!!!
enough said!
im getting tired about hearing about this, i just want to know now what the main event will be already....